Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety† †Electronic supplementary information (ESI) available. CCDC 154150–154153. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7ob02289a
نویسندگان
چکیده
A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6-pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF5-substituted oxindoles with a range of aldehydes. The resulting products were characterized by X-ray crystallography studies and were tested for biological activity versus a panel of cell lines and protein kinases. Some exhibited single digit nM activity.
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School of Chemistry and EaStCHEM, Un Andrews, Fife KY16 9ST, UK. E-mail: d.ph 463808; Tel: +44 (0)1334 467264 Institut de Génétique et de Biologie Molécu UMR 7104, Université de Strasbourg, Graffenstaden, France † Electronic supplementary information ( methods, synthesis and characterisation CCDC 1442418–1442421. For ESI and c electronic format see DOI: 10.1039/c6sc01 Cite this: Chem. Sci., 201...
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